homehome Home chatchat Notifications


Scientists transfer memories between snails with RNA implants

Memory may be far more complex than meets the eye.

Tibi Puiu
June 20, 2019 @ 7:13 pm

share Share

 

The California sea hare, Aplysia californica. Credit: Wikimedia Commons.

The California sea hare, Aplysia californica. Credit: Wikimedia Commons.

An exciting new research study suggests the possibility that some memories can be transferred between organisms. Scientists extracted ribonucleic acid (RNA) from a trained sea snail and implanted it into an untrained snail, whose behavior then matched that of the donor animal.

Where is my mind?

When the brain deems an experience meaningful enough, it will transfer that information from short-term storage — the temporary file cabinet which holds information like where you put your car keys or the phone number of a person you just met — to your long-term memory, where information is stored so that it can be accessed at a later time. Scientists think that this record is made in the brain by strengthening the connections between groups of neurons that participate in encoding the experience a pattern of connections which is referred to as an engram.

In 2012, MIT researchers identified the particular brain cells in the hippocampus that were active only when a mouse was learning about a new environment. They then proceeded to identify which genes were activated in those cells and added the gene for channelrhodopsin-2 (ChR2), a light-activated protein used in optogenetics, into a genetically engineered mouse. Using tiny optical fibers embedded in the animals’ skulls, the researchers could deliver pulses of light to hippocampal dentate gyrus neurons, thereby manipulating their activity. 

The mice were introduced to a new environment and were then left to acclimate themselves with a few minutes of exploration. A mild foot shock was then suddenly introduced, causing the mice to fear that environment. The activated brain cells were tagged with ChR2. Later, the mice were introduced in a totally different environment, with an obviously different maze and smell, and were again left there to explore. A pulse of light was fired onto the neurons involved in the first experience, causing the fear memory to switch on and the mice to quickly enter a defensive, immobile crouch. The rodents had, essentially, been fear conditioned.

“Our results show that memories really do reside in very specific brain cells,” co-author Xu Liu stated at the time, “and simply by reactivating these cells by physical means, such as light, an entire memory can be recalled.”

This landmark research study showed that long-term memories are stored in modified connections between brain cells, which can be recalled on command. However, recent evidence also points to an alternative explanation: memories might be stored in changes in gene expression induced by non-coding RNA (ncRNA) — an RNA molecule that is not translated into a protein.

Credit: Bédécarrats et al., eNeuro (2018).

Credit: Bédécarrats et al., eNeuro (2018).

David Glanzman and colleagues at the University of California, Los Angeles, trained a California sea hare (Aplysia californica) to form a conditioned response by stimulating their tail, triggering an involuntary defensive reflex. The team then proceeded to extract RNA from these trained snails and injected it into untrained animals. The latter group inherited a similar sensitized response.

Researchers also showed that RNA extracted from trained snails increased the excitability of cultured sensory neurons, which were obtained from untrained animals and which controlled the involuntary reflex.

The findings provide evidence that RNA may be involved in memory modification, which suggests that memory storage is far more complex than meets the eye.

Reference: RNA from Trained Aplysia Can Induce an Epigenetic Engram for Long-Term Sensitization in Untrained Aplysia, eNeuro.

share Share

A Fossil So Strange Scientists Think It’s From a Completely New Form of Life

This towering mystery fossil baffled scientists for 180 Years and it just got weirder.

ChatGPT Seems To Be Shifting to the Right. What Does That Even Mean?

ChatGPT doesn't have any political agenda but some unknown factor is causing a subtle shift in its responses.

This Freshwater Fish Can Live Over 120 Years and Shows No Signs of Aging. But It Has a Problem

An ancient freshwater species may be quietly facing a silent collapse.

The US wants to know if researchers in other countries follow MAGA doctrine

Science and policy are never truly free from one another. But one country's policy doesn't typically cross borders.

A Week of Cold Plunges Could Help Your Cells Fight Aging and Disease

Cold exposure "trains" cells to be more efficient at cleaning themselves up.

England will start giving morning-after pill for free

Free contraception in the UK clashes starkly with the US under Trump's shadow.

Japan’s Cherry Blossoms Are Blooming Earlier Than Ever. Guess Why

Climate change is disrupting natural cycles.

The most successful space telescope you never heard of just shut down

An astronomer says goodbye to Gaia, the satellite that mapped the galaxy.

A Gene-Edited Pig Liver Was Hooked to a Human for 10 Days and It Actually Worked

Breakthrough transplant raises hopes for patients needing liver support or awaiting transplants.

If you use ChatGPT a lot, this study has some concerning findings for you

So, umm, AI is not your friend — literally.