homehome Home chatchat Notifications


Modified cold sore virus shrinks melanoma tumors

There’s few things I can think of that sound scarier that a genetically modified version of herpes simplex virus type 1, but apparently that’s exactly what researchers used to shrink tumors of the deadly skin cancer melanoma in a clinical trial, according to Amgen, which is developing the experimental cancer treatment. The virus is actually […]

Mihai Andrei
March 22, 2013 @ 9:36 am

share Share

There’s few things I can think of that sound scarier that a genetically modified version of herpes simplex virus type 1, but apparently that’s exactly what researchers used to shrink tumors of the deadly skin cancer melanoma in a clinical trial, according to Amgen, which is developing the experimental cancer treatment.

herpes cancer The virus is actually the same virus that causes cold sores. Patients in the trial were either treated with it, or a drug called GM-CSF. 16 percent of the patients treated with the virus saw a partial or complete shrinkage of their tumors for at least six months – it may not seem like much, but compared to the 2 percent from the classical drug trial group, it’s a big improvement.

Amgen, one of the world’s biggest pharma companies purchased the company that developed the virus, Biovex, in 2011 for $425 million in cash and a commitment to pay up to $575 million if Biovex’s medicines hit certain milestones. So far, they seem well on track to meet those milestones, and we may be looking at one of the better plans to fight cancer. We’ll just see what happens next.

“These are the first Phase 3 results of this novel approach to cancer therapy,” said Sean E. Harper, M.D., executive vice president of Research and Development at Amgen. “A high unmet need exists in melanoma and we believe the innovative mechanism of action of talimogene laherparepvec may offer a promising approach for these patients.”

share Share

Your Brain Hits a Metabolic Cliff at 43. Here’s What That Means

This is when brain aging quietly kicks in.

Scientists Turn to Smelly Frogs to Fight Superbugs: How Their Slime Might Be the Key to Our Next Antibiotics

Researchers engineer synthetic antibiotics from frog slime that kill deadly bacteria without harming humans.

This Popular Zero-Calorie Sugar Substitute May Be Making You Hungrier, Not Slimmer

Zero-calorie sweeteners might confuse the brain, especially in people with obesity

Any Kind of Exercise, At Any Age, Boosts Your Brain

Even light physical activity can sharpen memory and boost mood across all ages.

Using screens in bed increases insomnia risk by 59% — but social media isn’t the worst offender

Forget blue light, the real reason screens disrupt sleep may be simpler than experts thought.

An Experimental Drug Just Slashed Genetic Heart Risk by 94%

One in 10 people carry this genetic heart risk. There's never been a treatment — until now.

We’re Getting Very Close to a Birth Control Pill for Men

Scientists may have just cracked the code for male birth control.

A New Antibiotic Was Hiding in Backyard Dirt and It Might Save Millions

A new antibiotic works when others fail.

A Week of Cold Plunges Could Help Your Cells Fight Aging and Disease

Cold exposure "trains" cells to be more efficient at cleaning themselves up.

England will start giving morning-after pill for free

Free contraception in the UK clashes starkly with the US under Trump's shadow.