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Martin Shkreli, chief executive officer of Turing Pharmaceuticals, became over night one of the most despised figures in the pharmaceutical industry when just as suddenly he raised the price of the only treatment of a rare parasitic infection by 5,000 percent. The drug, Daraprim, was initially developed in 1953 and used to cost $1 a pill only a couple years ago. I have no idea what Shkreli thought would happen after he'd raise the price 500-fold in one go, but he got some serious backlash. "I think that it makes sense to lower the price in response to the anger that was felt by people," he said while under the spotlight, but this promise made a month ago is still unfulfilled shattering whatever credibility Shkreli had left.
A new, extremely worrying study found that a third of meta-analyses related to antidepressant studies are written by pharma industry employees.
Marijuana use has doubled among American adults from 2001 to 2013. About 10% of the population or 22 million are believed to be recreational users, a steep rise driven by both cultural shifts and more permissive laws. About 1 in 3 users abuse the drug (continued use despite knowing it may be damaging health or causing depression or anxiety), though it's worth mentioning that this ratio was the same before the exponential rise in marijuana users.
"No amount of alcohol should be considered safe to drink during any trimester of pregnancy," wrote the the American Academy of Pediatrics in a report which identified ingesting alcohol during pregnancy as the leading cause of preventable birth defects.
Carbon nanotubes are a class of advanced materials that researchers think will transform electronics someday, but while great effort is expended trying to figure out the best way to make them, it appears that our lungs are already littered with them. American and French researchers collected both biological samples from randomly selected asthma patients and swabs from nearby buildings and busy intersections. Eventually they found carbon nanotubes, leading them to believe that the material is expelled throughout the city. The source? Vehicles, it seems, which act like carbon nanotube factories on wheels. Similar findings were detected in samples from Houston, in spider webs in India and in ice cores, suggesting carbon nanotubes are everywhere where automobiles are on the loose.
The current procedure for Ebola survivors is wait 42 consecutive days for the tests to come back negative, then the patients can be discharged from quarantine. More and more evidence is surfacing, however, showing that the virus can still linger on through various nooks and crannies in the human body, undetected from standard testing. For instance, one man was treated for Ebola, but the virus was still present in his eyes. It wasn't dormant either, since the inflammation caused his normally blue eyes to turn into green. Other evidence suggests Ebola can linger in the testes and be transmitted through sexual contact, but also in the uterus and joints. Only the case where Ebola was present in semen led to a transmission of the disease, so survivors aren't necessary contagious. These serious findings do suggest more quarantine measures are required, though.
Defecating outside comes at a great toll to the numerous, and often crowded Indian people. Lack of basic hygiene means hundreds of millions are exposed to bacterial pathogens and children are at the mercy of diarrhea. Economically speaking, this translated to $53.8 billion or 6.4 percent from India’s gross domestic product in 2006, says the World Bank.
What exactly makes you thirsty? Dehydration, obviously, but how does your brain know that your body needs water? And how does that grey, squishy lump resting in your cool and comfortable cranium, know when your body needs to heat up or cool off? Scientists at the McGill University Health Centre Research Institute (RI-MUHC) and Duke University have asked themselves just that, and being scientists, went ahead to find out.
Scientists have in the past toyed with the idea of using a disease to fight cancer. Now, after identifying a malaria protein that binds to cancer cells and kills 95% of tumor types, human trials are expected to start within four years. I doesn’t seem like it’s happening fast, but it is, in medical terms. Clinical […]
A research effort at Winship Cancer Institute recently identified a substance in orange lichen and rhubarb that has the potential to be used as a new anti-cancer drug. The substance, an orange pigment known as parietin or physcion, slows the growth and can even kill leukemia cells harvested from patients, without obvious toxic effects on human cells, the study authors report.
In the fight with cancer, we need any piece of help we can get. With this in mind, a group of researchers set out to investigate the animals that don't get cancer (or rarely do) - especially elephants and naked mole rats.
Researchers have discovered a new species of banana christened "nanensis", belonging to the Musa genus, sharing a place in the family Musaceae with more than 70 other species of bananas and plantains. It's scientific name honors the province of Nan where the type specimens were collected.
Prosthetics has come a long way from its humble beginnings – the crude wooden legs of yore are a far cry from the technological marvels we can create to replace our limbs today. However, there is one thing that, with all our know-how, we haven’t yet been able to incorporate in them: a sense of touch. A research team from Stanford University aims to fix this shortcoming, and has developed technology that can “feel” when force is exerted upon it, then transmit the sensory data to brain cells – in essence, they’ve created an artificial skin.
An unexpected correlation was discovered between the preference for bitter foods and everyday sadism an psychopathy, according to a new study published in the journal Appetite.
We've reported some good news about Ebola, after no new cases were reported for over a month, but the struggle is not over.
Chinese researchers discovered a chemical compound that works just as well as morphine -- without any of the negative side effects. The substance is derived from the venom of a centipede native to China. The discovery has huge medical applications, and could potentially reduce the country's military reliance on morphine for battlefield use.
Chronic inflammation of the colon has been recognized as a leading factor contributing to senescence and age-related diseases. Previously, scientists identified polyamines (PAs) levels, which are aliphatic low- molecular compounds, as being linked with systemic inflammation. The more PAs you have, the healthier your gut. But as we age, PAs levels fall and intestinal barrier dysfunction may occur. To test how significant is this contribution, researchers from Japan fed mice with probiotic supplements than compared them to a control. They found the mice lived longer, suggesting "ingestion of specific probiotics may be an easy approach for improving intestinal health and increasing lifespan."
Researchers stumbled upon a new tool to fight cancer in a rather unexpected place; while searching for a vaccine against malaria in pregnant women, a team of Danish scientists found that, simply put, armed malaria proteins are remarkably good at killing cancer cells. They hope to have a working prototype ready for human trials within four years' time. Their discovery has been published in the scientific journal Cancer Cell.
DNA – you either know is as deoxyribonucleic acid, or that stuff that somehow makes us what we are. DNA is the body’s way of storing information about yourself: how the cells arrange in your body, how hereditary material is organized, and how you function. DNA is classically thought of as a distinctive double helix structure, […]
With the variety of games available today varying from those designed to enhance mental fitness, solve real world problems all the way to ones meant for pure entertainment, they have diverse and profound effects on our brains. A new article published in the October 1st issue of Policy Insights from the Behavioral and Brain Sciences argues that the specific content, dynamics, and mechanics of individual games determine their effects on the brain and that the long-criticized action video games might have particularly positive benefits.
Capitalizing a more than a decade's worth of neuroscience and computer science research, an international team of 82 researchers from institutions around the world report one the most detailed digital reconstruction of a mammalian brain. The researchers simulated 30,000 neurons and almost 40 million synapses, part of a rat's brain measuring less than a third of a cubic millimeter. It's a small step that might one day help simulate the whole brain, not just of rats, but also of humans - the ultimate goal of the Human Brain Project (HBP), an ambitious project which the European Commission prioritized and awarded $1 billion in funding.
The complete genetic code book of a person who lived 4,500 years ago in Ethiopia was completed by US researchers. Although much older genomes have been sequenced, like those of 38,000 year-old Neanderthals, samples from African forefathers have proven difficult to sequence as the DNA is often destroyed by accelerated decay, driven by tropical conditions. As such, this is the first time a complete genome retrieval was performed from an ancient human in Africa. In this light, the findings are very important: they suggest even older DNA could be retrieved - maybe even millions of years back to the age of other species of the homo genus.
Are homosexuals hard wired this way or merely the product of their environment? Some argue that its both, but whether or not there's a 'gay gene' or more is up to debate. The fact that it's such a delicate subject, i.e. hard to get funding, means that progress is slow. One could argue that it wouldn't be worth researching anyway. If someone found a scientific causal-link, say some genes, that's responsible for homosexuality than it's possible to maybe reverse it. A 'cure' for homosexuality, if you will. Even this very prospect is enough to kill research out of politically correctness. At the American Society of Human Genetics (ASHG) in Baltimore, however, the audience might have been surprised to hear about the findings of a group from University of California (UC), Los Angeles that found there's reasons to believe homosexuality is rooted in epigenetics. The authors are quick to caution that their findings are far from being the final word, and hence should be taken with a grain of salt.
Among all the species with which we share the animal kingdom, pigs are the ones whose organs are best suited for transplant in human bodies -- they are approximately the same size as our organs and have similar structures, making reconnecting blood vessels much easier. Pigs tend to have large litters and reproduce quickly, making them a very large, very accessible source of "spare parts."
It's estimated that humanity will have to produce around 50% more food than we currently do to keep up with growing global demand....by 2050. It's an enormous challenge, especially as more and more countries face the effects of climate change, such as drought or toxic salinity levels. One of our best hopes is to rely more on crops that can flourish despite the vicissitudes of the environment, and plant cell biologists at the University of Oxford hope that their new breakthrough in climate-resilient agriculture will allow us to do just that.
The feel-good, floating sensation people get after a good run is analogous to smoking pot. Researchers came to the conclusion after they found mice released chemicals in the brain that bind to the same brain receptors which are triggered when one smokes the herb. The practical implications of the research are limited, but they do seem to suggest that evolution fostered running otherwise it wouldn't have been this pleasurable.
It's the first time since March 2014 that the three African countries at the heart of the Ebola epidemic have not reported a new case of the outbreak.
Scientists have developed devices that move us one step closer towards eliminating the need for animal testing. These working miniature artificial brains would be ideal for testing drugs research, neural tissue transplants, or experiments with stem cells.
The brain forms new thoughts using two adjacent brain regions that are the cornerstone of the process.
Chilly peppers: hate them or love 'em. Few could have imagined the impact of Columbus' discovery of a spice in the XXVth century so pungent that it rivaled the better known black pepper native to South Asia. In only a couple of years ago, the red chilly was planted all over the globe after being brought from South and Central America. Today, it's one of the most widely used spices in the world. But is chilly actually healthy? Many studies seem to contradict one another, so the debate is far from over. Some scientists claim chilly acts against cancer and helps us stay healthy, but at the same time chilly can hurt the inside of the stomach and esophagus and can even lead to internal bleeding. All foods have their good and bad sides, though, so probably people are more interested in the net effects of ingesting a certain food, chilly or otherwise - doesn't matter. And finally, there's a study that seems to suggest that, overall, chilly is our friend. That's according to Chinese researchers who tracked the eating and health habits of 500,000 individuals and found those who ingested chilly at least two times a week had a mortality rate 10% lower than those who only seldom ate chilly or not at all. Those who ate the devilish spice six or seven days a week had an even lower risk of dying.
For most people listening to music or playing an instrument is a great way to relax, unwind, have fun, and express themselves. But not everybody is able to perceive, appreciate or memorize music, to sing or to dance. Monica is one such person, and to her, any kind of music is just a bunch of noise that makes her head ache and feel stressed.
A few days ago, we were telling you about a potentially groundbreaking study which found a rather surprising correlation between height and cancer incidence. The study made quite a wave within the scientific community and was met with quite mixed opinions. Here are some of those impressions, from leading experts in the field. Prof Mel […]
Two drugs, currently prescribed to organ transplant patients to suppress their immune system after the procedure, show great promise as birth-control medicine for men, according to a study published in the journal Science.
For every extra 10 cm in height from the median, the chance of getting cancer increases by 11% for men and 18% for women. The link was reported by Swedish researchers at the European Society for Paediatric Endocrinology meeting in Barcelona, Spain. While other studies have reported this link, this was the largest yet performed involving 5.5 million Swedish men and women ranging in height from 1 meter (3.3 ft) to 2.25 meters (7.4 ft).
Yesterday, we wrote about how the Chinese will be selling genetically engineered micro-pigs as pets; the pigs, which were originally developed to serve as cheaper models for the human body, were engineered to grow only up to 25 kgs, but they also raise some important concerns: is it ethical? Should we engineer animals so that […]
Publication bias strikes again: because only positive results are published in scientific journals, medical literature greatly overstates the benefits of talk therapy for depression.
Drivers and passengers who light one up while kids are in the car now face fines in England in Wales, in an attempt to curve down the effects of passive smoking.
In what can only be classed as a breakthrough in medicine, a team at Washington University in St. Louis found a way to make an universal test that can identify virtually any known virus. The method works by analyzing bodily samples for signature genetic markers unique to each virus. It's surprisingly accurate, as the researchers report the test not only identified the viruses on par with standard tests, but found additional ones which would have otherwise gone unnoticed. Once it passes extensive clinical trials, doctors using the test could come up with a complete list of viral infections harbored inside a patient's body, correctly diagnose their condition and apply the right treatment. In some situations, it could mean the difference between life and death.
Many researchers have expressed concerns about using such advanced techniques for such frivolous purposes, and personally, I feel like this could cascade onto many other problems - despite their undeniable cuteness.
A new study conducted on medical consumption of cannabis came up with some good news, and some bad news: for starters, while there were some adverse effects on consumers, no serious effects were reported. However, the reduction in pain also seems to be very small.
Paleontologists believe they have found the oldest evidence of the bubonic plague, embedded in a flea trapped in amber for the past 20 million years. This could provide insight onto how this devastating disease appeared and evolved.
Our ability to inhibit impulsive behaviors, to exercise willpower, is considered a core feature of the brain's executive functions. This, along with others such as reasoning, working memory and attention regulate our thoughts and guide our behavior, allowing us to adapt them to the changing demands of our environment. But the effort our brain puts into refraining from impulses is so great that it can actually diminish its ability to form memories of the experience.
Fewer materials in nature rival the toughness and resilience of a tooth or a seashell, and it's all due to their unique structure; viewed under powerful enough microscope, they reveal layers upon layers of micro-plates, perfectly aligned and fused together. Material scientists have long sought to produce something that imitates these structures, with comparable properties and complexity, but apart from nacre (mother-of-pearl) they've had very little success. Until now.
After they analyzed more than 2,000 traditional Indian recipes down to the molecular levels, scientists now think they know what makes Indian cuisine so appealing. Unlike western dishes, Indian recipes are based on ingredients whose flavors don't overlap for a unique taste that dumbstrucks anyone who tries it for the first time.
Each memory relies on three critical elements, those being the "what," "where" and "when" building blocks. Neuroscientists from MIT have identified a brain circuit -- connecting the hippocampus and a region of the cortex known as entorhinal cortex -- that handles the "when" and "where" components.
University of Washington researchers have created the first telepathic link between two humans. Their technique didn't rely on supernatural powers, but rather on nerve impulses, electrodes, and advanced science.
Enamel, the hard, mineralized substance that covers your teeth originated on tough fish scales and then migrated to the teeth, researchers found
New research suggests that simply fidgeting around could counter some of the effects of sitting down for too long.
For the first time, Japanese researchers have successfully grown a pair of kidneys in a lab and then transplanted them into animals. The organs functioned just fine, and this gives big hopes for the transplants ultimately moving to humans.
Humans are walking ecosystems. Each of us carries around about 100 trillion microbes in and on our bodies, which make up our microbiome. The quality of this bacterial community has a lot to say about our health and well-being. The blend of microbes is also surprisingly unique, which says a lot about who we are […]
