Don Arnold -- author profile on ZME Science

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Don Arnold

Professor Arnold studies how information is encoded in synapses. Modifying the network of synaptic connections between neurons is thought to be the main mechanism for storing information in the brain. The Arnold laboratory has developed novel recombinant probes known as FingRs that allow us to visualize and ablate synaptic connections in living organisms. We are using this technology to study how synapses change when a memory is formed in a behaving animal. We are also adapting this technology to enable the modification or erasure of memories in vivo through the ablation of synapses in a light-dependent manner. We are particularly interested in the mechanisms by which maladaptive memories, such as associative memories that can lead to PTSD or addiction, are formed. Ultimately, our goal is to use our technology to erase or modify such memories.

In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron. Credit: NIH Image Gallery.

Where are memories stored in the brain? They may be hidding in the connections between your brain cells

byDon Arnold

January 11, 2022

Understanding where and how memories are formed could lead to more ways to treat conditions like PTSD and addiction.

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